Can individually targeted and optimized multi-channel tDCS outperform standard bipolar tDCS in stimulating the primary somatosensory cortex?
Background: Transcranial direct current stimulation (tDCS) has emerged as a non-invasive neuro-modulation technique. Most studies show that anodal tDCS increases cortical excitability, however, withvariable outcomes. Previously, we have shown in computer simulations that our multi-channel tDCS (mc-t...
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| FB/Einrichtung: | FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2022 |
| Publikation in MIAMI: | 21.02.2023 |
| Datum der letzten Änderung: | 27.02.2023 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Brain Stimulation 16 (2023) 1, 1–16 |
| Schlagwörter: | Multi-channel transcranial direct current stimulation (mc-tDCS); mc-tDCS montage optimization; Individualization; Targeting; Magnetoencephalography (MEG); Electroencephalography (EEG); Source analysis; Finite element method (FEM); Skull conductivity calibration |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY-NC-ND 4.0 |
| Sprache: | English |
| Förderung: | Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster). Förderer: Federal Ministry of Health / Projektnummer: ZMI1-2521FSB006 Förderer: Deutsche Forschungsgemeinschaft / Projektnummer: 448089231 Förderer: Deutsche Forschungsgemeinschaft / Projektnummer: 239180637 |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-81019488399 |
| Weitere Identifikatoren: | DOI: 10.17879/31029742522 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-81019488399 |
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| Onlinezugriff: | 10.1016_j.brs.2022.12.006.pdf |
Background: Transcranial direct current stimulation (tDCS) has emerged as a non-invasive neuro-modulation technique. Most studies show that anodal tDCS increases cortical excitability, however, withvariable outcomes. Previously, we have shown in computer simulations that our multi-channel tDCS (mc-tDCS) approach, the distributed constrained maximum intensity (D-CMI) method can potentially lead to better controlled tDCS results due to the improved directionality of the injected current at the target side for individually optimized D-CMI montages. Objective: In this study, we test the application of the D-CMI approach in an experimental study to stimulate the somatosensory P20/N20 target source in Brodmann area 3b and compare it with standard bipolar tDCS and sham onditions. Methods: We applied anodal D-CMI, the standard bipolar and D-CMI based Sham tDCS for 10 min to target the 20 ms post-stimulus somatosensory P20/N20 target brain source in Brodmann area 3b reconstructed using combined magnetoencephalography (MEG) and electroencephalography (EEG) source analysis in realistic head models with calibrated skull conductivity in a group-study with 13 subjects. Finger-stimulated somatosensory evoked fields (SEF) were recorded and the component at 20 ms post-stimulus (M20) was analyzed before and after the application of the three tDCS conditions in order to read out the stimulation effect on Brodmann area 3b. Results: Analysis of the finger stimulated SEF M20 peak before (baseline) and after tDCS shows a significant increase in source amplitude in Brodmann area 3b for D-CMI (6-16 min after tDCS), while no significant effects are found for standard bipolar (6-16 min after tDCS) and sham (6-16 min after tDCS) stimulation conditions. For the later time courses (16-26 and 27-37 min post-stimulation), we found a significant decrease in M20 peak source amplitude for standard bipolar and sham tDCS, while there was no effect for D-CMI. Conclusion: Our results indicate that targeted and optimized, and thereby highly individualized, mc-tDCS can outperform standard bipolar stimulation and lead to better control over stimulation outcomes with, however, a considerable amount of additional work compared to standard bipolar tDCS.