Development of Novel Isoindolone-Based Compounds against Trypanosoma brucei rhodesiense
This study identified the isoindolone ring as a scaffold for novel agents against 'Trypanosoma brucei rhodesiense' and explored the structure-activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibi...
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| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2021 |
| Publikation in MIAMI: | 18.04.2023 |
| Datum der letzten Änderung: | 18.04.2023 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | ChemistryOpen 10 (2021) 9, e202100180 1-6 |
| Schlagwörter: | anti-infectives; heterocyclic; in vitro; T. b. brucei; T. b. rhodesiense |
| Fachgebiet (DDC): | 540: Chemie |
| Lizenz: | CC BY-NC 4.0 |
| Sprache: | English |
| Förderung: | Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022. |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-20069625538 |
| Weitere Identifikatoren: | DOI: 10.17879/10089550741 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-20069625538 |
| Verwandte Dokumente: |
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| Onlinezugriff: | 10.1002_open.202100180.pdf |
This study identified the isoindolone ring as a scaffold for novel agents against 'Trypanosoma brucei rhodesiense' and explored the structure-activity relationships of various aromatic ring substitutions. The compounds were evaluated in an integrated in vitro screen. Eight compounds exhibited selective activity against 'T. b. rhodesiense' (IC50