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Itch Perception and Skin Reactions as Modulated by Verbal Suggestions: Role of Participant’s and Investigator’s Sex

This study investigated sex-specific differences in itch perception and skin reactions, as modulated by verbal suggestions, and the role of the investigator’s sex. Healthy volunteers (50 males, 50 females), divided into 4 groups, were tested by male and female investigators. Itch was induced via prick testing with sodium chloride and histamine in 4 runs; 2 control conditions (with no exaggerated verbal comments about expected itch) and 2 experimental conditions (with exaggerated verbal comments). After 5 min, wheal and flare reactions were measured and itch intensity was rated by subjects on a numerical rating scale. Exaggerated verbal suggestions resulted in higher itch intensity ratings in the sodium chloride and histamine condition, and higher unpleasantness ratings and a wheal of greater extent in the sodium chloride condition, as well as a flare of greater extent in the histamine condition. The magnitude of the differences between the exaggerated verbal suggestion conditions and respective control conditions was only significantly different between male and female investigators concerning flare size in the histamine condition. There were no differences between male and female participants. Therefore, sex differences may play only a minor role in nocebo-induced itch perception.

Titel: Itch Perception and Skin Reactions as Modulated by Verbal Suggestions: Role of Participant’s and Investigator’s Sex
Verfasser: Stumpf, Astrid GND
Zerey, Volkan
Heuft, Gereon GND
Ständer, Sonja GND
Pfleiderer, Bettina GND
Schneider, Gudrun
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 20.12.2015
Publikation in MIAMI: 13.09.2016
Datum der letzten Änderung: 16.04.2019
Quelle: Acta Dermato-Venereologica 96 (2016) 5, 619–623
Schlagwörter: sex; subject; investigator; pruritus-perception; skin reaction; suggestibility
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY-NC 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-54279512385
DOI: 10.2340/00015555-2336
ISSN: 0001-5555