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Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation

The central processing of itch is not completely understood. This is the first study to use functional magnetic resonance imaging (fMRI) to examine the central modulation by distraction of experimentally induced itch. A total of 33 healthy volunteers were examined with fMRI. Periods of itch induction without distraction and itch with distraction by a Stroop task (psychological test, where the participants have to decide if the colour of the writing corresponds to the written word, for example if ”red” is written in red or not) were counterbalanced during the scanning to examine task-specific changes in blood oxygenation level dependent-signal. The intensity of the subjects’ itch sensation, desire to scratch and pain sensation were evaluated. Distraction by a Stroop task did not reduce itch intensity or urge to scratch. However, the Stroop task led to significantly higher activation of the left brainstem when it followed the “pure” itch sensation. Itch and pain seem to have similar inhibition pathways, particularly concerning brainstem activation during distraction. But as itch sensation, in contrast to pain, could not be sufficiently reduced by distraction, both entities might have different modulation systems.

Titel: Distraction From Itch Shows Brainstem Activation Without Reduction in Experimental Itch Sensation
Verfasser: Stumpf, Astrid GND
Pfleiderer, Bettina GND
Schneider, Gudrun
Heuft, Gereon GND
Schmelz, Martin
Phan, Ngoc Quan GND
Ständer, Sonja GND
Burgmer, Markus GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 27.06.2018
Publikation in MIAMI: 06.12.2018
Datum der letzten Änderung: 06.12.2018
Quelle: Acta Dermato-Venereologica (2017) 97, 1074-1080
Schlagwörter: fMRI; itch; scratch; pain; pain inhibition system
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY-NC 4.0
Sprache: Englisch
Förderung: Finanziert durch den Open-Access-Publikationsfonds 2017 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-06169568021
DOI: 10.2340/00015555-2732