Fast Tac Metabolizers at Risk—It is Time for a C/D Ratio Calculation

Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal func...

Authors: Schütte-Nütgen, Katharina
Thölking, Gerold Bernhard
Steinke, Julia
Pavenstädt, Hermann
Schmidt, René
Suwelack, Barbara
Reuter, Stefan Johannes
Division/Institute:FB 05: Medizinische Fakultät
Document types:Article
Media types:Text
Publication date:2019
Date of publication on miami:17.02.2020
Modification date:17.02.2020
Edition statement:[Electronic ed.]
Source:Journal of Clinical Medicine 8 (2019) 5, 587, 1-15
Subjects:kidney transplantation; tacrolimus; C/D-ratio; pharmacokinetics
DDC Subject:610: Medizin und Gesundheit
License:CC BY 4.0
Language:English
Notes:Eine Korrektur dieses Artikels befindet sich in: Journal of Clinical Medicine 8 (2019) 11, 1870
Funding:Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
URN:urn:nbn:de:hbz:6-02129393408
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-02129393408
Other Identifiers:DOI: 10.3390/jcm8050587
Digital documents:artikel_reuter_2019.pdf

Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal function after RTx. Therefore, we hypothesize that the Tac metabolism rate impacts patient and graft survival after RTx. We analyzed all patients who received a RTx between January 2007 and December 2012 and were initially treated with an immunosuppressive regimen containing Tac (Prograf®), mycophenolate mofetil, prednisolone and induction therapy. Patients with a Tac C/D ratio