Fast Tac Metabolizers at Risk—It is Time for a C/D Ratio Calculation
Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal func...
| Verfasser: | |
|---|---|
| FB/Einrichtung: | FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2019 |
| Publikation in MIAMI: | 17.02.2020 |
| Datum der letzten Änderung: | 17.02.2020 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Journal of Clinical Medicine 8 (2019) 5, 587, 1-15 |
| Schlagwörter: | kidney transplantation; tacrolimus; C/D-ratio; pharmacokinetics |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY 4.0 |
| Sprache: | English |
| Anmerkungen: | Eine Korrektur dieses Artikels befindet sich in: Journal of Clinical Medicine 8 (2019) 11, 1870 |
| Förderung: | Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster). |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-02129393408 |
| Weitere Identifikatoren: | DOI: 10.3390/jcm8050587 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-02129393408 |
| Verwandte Dokumente: |
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| Onlinezugriff: | artikel_reuter_2019.pdf |
Tacrolimus (Tac) is a part of the standard immunosuppressive regimen after renal transplantation (RTx). However, its metabolism rate is highly variable. A fast Tac metabolism rate, defined by the Tac blood trough concentration (C) divided by the daily dose (D), is associated with inferior renal function after RTx. Therefore, we hypothesize that the Tac metabolism rate impacts patient and graft survival after RTx. We analyzed all patients who received a RTx between January 2007 and December 2012 and were initially treated with an immunosuppressive regimen containing Tac (Prograf®), mycophenolate mofetil, prednisolone and induction therapy. Patients with a Tac C/D ratio