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Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer

Objectives: PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand therapy in patients with metastasized prostate cancer. Since PSMA expression is not restricted to prostate cancer, the underlying study investigates PSMA expression in non-small cell lung cancer (NSCLC). Material and methods: Immunohistochemistry was used to identify PSMA expression in n = 275 samples of NSCLC tissue specimens. By means of CD34 co-expression, the level of PSMA expression in tumor associated neovasculature was investigated. The impact of PSMA expression on clinicopathologic parameters and prognosis was evaluated. Results: PSMA tumor cell expression in NSCLC is as low as 6% and was predominantly found in squamous cell carcinoma (p = 0.002). Neovascular PSMA expression was found in 49% of NSCLC. High neovascular PSMA expression was associated with higher tumor grading (G3/G4) (p < 0.001). Neither for PSMA tumor cell expression, nor for PSMA neovascular cell expression prognostic effects were found for the investigated NSCLC cases. Conclusion: Here, we report on the expression of PSMA in NSCLC tissue samples. Against the background of a potential treatment with radiolabeled PSMA ligands, our data might serve for the future identification of patients who could benefit from this therapeutic option.

Titel: Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer
Verfasser: Schmidt, Lars Henning GND
Heitkötter, Birthe Franziska GND
Schulze, Arik Bernard GND
Schliemann, Christoph GND
Steinestel, Konrad Ernst GND
Trautmann, Marcel GND
Marra, Alessandro GND
Hillejan, Ludger GND
Mohr, Michael GND
Evers, Georg Heribert GND
Wardelmann, Eva GND
Rahbar, Kambiz GND
Görlich, Dennis GND
Lenz, Georg GND
Berdel, Wolfgang E. GND
Hartmann, Wolfgang
Wiewrodt, Rainer Gerhard GND
Huss, Sebastian GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 27.10.2017
Publikation in MIAMI: 21.03.2019
Datum der letzten Änderung: 16.04.2019
Quelle: PLoS ONE 12 (2017) 10, e0188262, 1-12
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 4.0
Sprache: Englisch
Förderung: Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-45159558749
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-45159558749
DOI: 10.1371/journal.pone.0186280
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