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|a urn:nbn:de:hbz:6-45159558749
|2 urn
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|a 10.1371/journal.pone.0186280
|2 doi
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|a eng
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|a 610 Medizin und Gesundheit
|2 23
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|a Schmidt, Lars Henning
|0 http://d-nb.info/gnd/133785505
|4 aut
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|a Universitäts- und Landesbibliothek Münster
|0 http://d-nb.info/gnd/5091030-9
|4 own
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|a Prostate specific membrane antigen (PSMA) expression in non-small cell lung cancer
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|a [Electronic ed.]
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|c 2017-10-27
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|b Universitäts- und Landesbibliothek Münster
|c 2019-03-21
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|a 1-12
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|a free access
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|a PLoS ONE 12 (2017) 10, e0188262, 1-12
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|a Objectives: PSMA (prostate-specific membrane antigen) is overexpressed in prostate cancer cells and is reported to be a promising target for antibody-based radioligand therapy in patients with metastasized prostate cancer. Since PSMA expression is not restricted to prostate cancer, the underlying study investigates PSMA expression in non-small cell lung cancer (NSCLC). Material and methods: Immunohistochemistry was used to identify PSMA expression in n = 275 samples of NSCLC tissue specimens. By means of CD34 co-expression, the level of PSMA expression in tumor associated neovasculature was investigated. The impact of PSMA expression on clinicopathologic parameters and prognosis was evaluated. Results: PSMA tumor cell expression in NSCLC is as low as 6% and was predominantly found in squamous cell carcinoma (p = 0.002). Neovascular PSMA expression was found in 49% of NSCLC. High neovascular PSMA expression was associated with higher tumor grading (G3/G4) (p < 0.001). Neither for PSMA tumor cell expression, nor for PSMA neovascular cell expression prognostic effects were found for the investigated NSCLC cases. Conclusion: Here, we report on the expression of PSMA in NSCLC tissue samples. Against the background of a potential treatment with radiolabeled PSMA ligands, our data might serve for the future identification of patients who could benefit from this therapeutic option.
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|a specialized
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|a Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
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|a CC BY 4.0
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|a Heitkötter, Birthe Franziska
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|a Schulze, Arik Bernard
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|a Schliemann, Christoph
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|a Steinestel, Konrad Ernst
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|a Mohr, Michael
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|a Hartmann, Wolfgang
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