Paclitaxel-eluting balloon dilation of biliary anastomotic stricture after liver transplantation

AIM: To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon (PEB) for biliary anastomotic stricture (AS) after liver transplantation (LT). METHODS: This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT...

Authors: Hüsing, Anna Katharina Elisabeth Pia
Reinecke, Holger
Cicinnati, Vito R.
Beckebaum, Susanne
Wilms, Christian
Schmidt, Hartmut
Kabar, Iyad
Division/Institute:FB 05: Medizinische Fakultät
Document types:Article
Media types:Text
Publication date:2015
Date of publication on miami:27.05.2015
Modification date:16.04.2019
Edition statement:[Electronic ed.]
Source:World Journal of Gastroenterology 21 (2015) 3, 977-981
Subjects:Liver transplantation; Anastomotic stricture; Endoscopic therapy; Endoscopic retrograde cholangiopancreatography; Balloon dilation; Paclitaxel-eluting balloon
DDC Subject:610: Medizin und Gesundheit
License:CC BY-NC 4.0
Language:English
Notes:Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
ISSN:2219-2840
URN:urn:nbn:de:hbz:6-19259678348
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-19259678348
Other Identifiers:DOI: http://dx.doi.org/10.3748/WJG.v21.i3.977
Digital documents:WJG-21-977.pdf

AIM: To investigate the safety and effectiveness of endoscopic therapy with a paclitaxel-eluting balloon (PEB) for biliary anastomotic stricture (AS) after liver transplantation (LT). METHODS: This prospective pilot study enrolled 13 consecutive eligible patients treated for symptomatic AS after LT at the University Hospital of Münster between January 2011 and March 2014. The patients were treated by endoscopic therapy with a PEB and followed up every 8 wk by endoscopic retrograde cholangiopancreatography (ERCP). In cases of re-stenosis, further balloon dilation with a PEB was performed. Follow-up was continued until 24 mo after the last intervention. RESULTS: Initial technical feasibility, defined as successful balloon dilation with a PEB during the initial ERCP procedure, was achieved in 100% of cases. Long-term clinical success (LTCS), defined as no need for further endoscopic intervention for at least 24 mo, was achieved in 12 of the 13 patients (92.3%). The mean number of endoscopic interventions required to achieve LTCS was only 1.7 ± 1.1. Treatment failure, defined as the need for definitive alternative treatment, occurred in only one patient, who developed recurrent stenosis with increasing bile duct dilatation that required stent placement. CONCLUSION: Endoscopic therapy with a PEB is very effective for the treatment of AS after LT, and seems to significantly shorten the overall duration of endoscopic treatment by reducing the number of interventions needed to achieve LTCS.