Annexin Animal Models—From Fundamental Principles to Translational Research

Routine manipulation of the mouse genome has become a landmark in biomedical research. Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into...

Verfasser: Grewal, Thomas
Rentero, Carles
Enrich, Carlos
Wahba, Mohamed
Raabe, Carsten A.
Rescher, Ursula
Dokumenttypen:Artikel
Medientypen:Text
Erscheinungsdatum:2021
Publikation in MIAMI:02.12.2022
Datum der letzten Änderung:02.12.2022
Angaben zur Ausgabe:[Electronic ed.]
Quelle:International Journal of Molecular Sciences 22 (2021) 7, 3439, 1-67
Schlagwörter:annexins; calcium; human disease models; KO mice; membrane trafficking; membrane organization; extracellular annexin functions
Fachgebiet (DDC):610: Medizin und Gesundheit
Lizenz:CC BY 4.0
Sprache:English
Förderung:Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF-Dokument
URN:urn:nbn:de:hbz:6-02009707412
Weitere Identifikatoren:DOI: 10.17879/32009425049
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-02009707412
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Onlinezugriff:10.3390_ijms22073439.pdf

Routine manipulation of the mouse genome has become a landmark in biomedical research. Traits that are only associated with advanced developmental stages can now be investigated within a living organism, and the in vivo analysis of corresponding phenotypes and functions advances the translation into the clinical setting. The annexins, a family of closely related calcium (Ca2+)- and lipid-binding proteins, are found at various intra- and extracellular locations, and interact with a broad range of membrane lipids and proteins. Their impacts on cellular functions has been extensively assessed in vitro, yet annexin-deficient mouse models generally develop normally and do not display obvious phenotypes. Only in recent years, studies examining genetically modified annexin mouse models which were exposed to stress conditions mimicking human disease often revealed striking phenotypes. This review is the first comprehensive overview of annexin-related research using animal models and their exciting future use for relevant issues in biology and experimental medicine.