Contaminant Metals and Cardiovascular Health

A growing body of research has begun to link exposure to environmental contaminants, such as heavy metals, with a variety of negative health outcomes. In this paper, we sought to review the current research describing the impact of certain common contaminant metals on cardiovascular (CV) health. We...

Authors: Lundin, Karl Kristian
Qadeer, Yusuf Kamran
Wang, Zhen
Virani, Salim
Leischik, Roman
Lavie, Carl J.
Strauß, Markus
Krittanawong, Chayakrit
Document types:Article
Media types:Text
Publication date:2023
Date of publication on miami:17.01.2024
Modification date:17.01.2024
Edition statement:[Electronic ed.]
Source:Journal of Cardiovascular Development and Disease 10 (2023) 11, 450, 1-33
Subjects:cardiovascular disease; metal toxicity; metals and cardiovascular disease; cardiovascular toxicity; cardiovascular metal toxicity; heart and metal toxicity; environmental contaminants and cardiovascular toxicity; heart toxicity; cardiac toxicity; environmental heart toxins; environmental cardiac toxins; cardiology and metals; cardiology and environmental science; cardiology and metal toxins; heart toxins; cardiac toxins
DDC Subject:610: Medizin und Gesundheit
License:CC BY 4.0
Language:English
Funding:Finanziert durch den Open-Access-Publikationsfonds der Universität Münster.
Format:PDF document
URN:urn:nbn:de:hbz:6-77988535848
Other Identifiers:DOI: 10.17879/77988538340
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-77988535848
Related records:
Digital documents:10.3390_jcdd10110450.pdf

A growing body of research has begun to link exposure to environmental contaminants, such as heavy metals, with a variety of negative health outcomes. In this paper, we sought to review the current research describing the impact of certain common contaminant metals on cardiovascular (CV) health. We reviewed ten metals: lead, barium, nickel, chromium, cadmium, arsenic, mercury, selenium, zinc, and copper. After a literature review, we briefly summarized the routes of environmen- tal exposure, pathophysiological mechanisms, CV health impacts, and exposure prevention and/or mitigation strategies for each metal. The resulting article discloses a broad spectrum of pathological significance, from relatively benign substances with little to no described effects on CV health, such as chromium and selenium, to substances with a wide-ranging and relatively severe spectrum of CV pathologies, such as arsenic, cadmium, and lead. It is our hope that this article will provide clinicians with a practical overview of the impact of these common environmental contaminants on CV health as well as highlight areas that require further investigation to better understand how these metals impact the incidence and progression of CV diseases.