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Hope for the best or prepare for the worst? Towards a spatial cognitive bias test for mice

Cognitive bias, the altered information processing resulting from the background emotional state of an individual, has been suggested as a promising new indicator of animal emotion. Comparable to anxious or depressed humans, animals in a putatively negative emotional state are more likely to judge an ambiguous stimulus as if it predicts a negative event, than those in positive states. The present study aimed to establish a cognitive bias test for mice based on a spatial judgment task and to apply it in a pilot study to serotonin transporter (5-HTT) knockout mice, a well-established mouse model for the study of anxiety- and depression-related behavior. In a first step, we validated that our setup can assess different expectations about the outcome of an ambiguous stimulus: mice having learned to expect something positive within a maze differed significantly in their behavior towards an unfamiliar location than animals having learned to expect something negative. In a second step, the use of spatial location as a discriminatory stimulus was confirmed by showing that mice interpret an ambiguous stimulus depending on its spatial location, with a position exactly midway between a positive and a negative reference point provoking the highest level of ambiguity. Finally, the anxiety- and depression-like phenotype of the 5-HTT knockout mouse model manifested - comparable to human conditions - in a trend for a negatively distorted interpretation of ambiguous information, albeit this effect was not statistically significant. The results suggest that the present cognitive bias test provides a useful basis to study the emotional state in mice, which may not only increase the translational value of animal models in the study of human affective disorders, but which is also a central objective of animal welfare research.

Titel: Hope for the best or prepare for the worst? Towards a spatial cognitive bias test for mice
Verfasser: Kloke, Vanessa GND
Schreiber, Rebecca Mina GND
Bodden, Carina GND
Möllers, Julian
Ruhmann, Hanna GND
Kaiser, Sylvia GND
Lesch, Klaus-Peter J. GND
Sachser, Norbert GND
Lewejohann, Lars GND
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 19.08.2014
Publikation in MIAMI: 05.12.2014
Datum der letzten Änderung: 16.04.2019
Quelle: PLOS one 9 (2014) 8, 1-12, e105431
Fachgebiete: Biowissenschaften; Biologie
Lizenz: CC BY 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-51329481171
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-51329481171
DOI: doi:10.1371/journal.pone.0105431
ISSN: 1932-6203
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