The change in plasma D-dimer does not help to guide the timing of reimplantation in two stage exchange for periprosthetic joint infection
D-dimer has been included in the criteria by the Musculoskeletal Infection Society in 2018 as a novel parameter to diagnose prosthetic joint infection (PJI). However, it is unclear how D-dimer levels change in between stages of a two-stage exchange. We prospectively investigated 30 patients who unde...
| Verfasser: | |
|---|---|
| FB/Einrichtung: | FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2021 |
| Publikation in MIAMI: | 25.10.2022 |
| Datum der letzten Änderung: | 25.10.2022 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Scientific Reports 11 (2021) 7323, 1-6 |
| Schlagwörter: | Biomarkers; Diagnostic markers |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY 4.0 |
| Sprache: | Englisch |
| Förderung: | Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022. |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-82039732830 |
| Weitere Identifikatoren: | DOI: 10.17879/32049570554 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-82039732830 |
| Verwandte Dokumente: |
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| Onlinezugriff: | 10.1038_s41598-021-86890-z.pdf |
D-dimer has been included in the criteria by the Musculoskeletal Infection Society in 2018 as a novel parameter to diagnose prosthetic joint infection (PJI). However, it is unclear how D-dimer levels change in between stages of a two-stage exchange. We prospectively investigated 30 patients who underwent a two-stage exchange using a spacer for PJI. D-Dimer, CRP and IL-6 were collected before first and second stage surgery and the difference (Δ) in between stages was calculated. The levels of plasma D-Dimer did not change from first to second stage surgery (2770 ng/ml (IQR, 1600–3770 ng/ml) versus 2340 ng/ml (IQR, 1270–4100 ng/ml); p = 0.8) while CRP (4.0 mg/dl (IQR, 1.7–5.5 mg/dl) versus 0.6 mg/dl (IQR, 0.5–0.8 mg/dl); p