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Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction

BACKGROUND: This retrospective, multicenter study aimed to reveal risk predictors for mortality in the intensive care unit (ICU) as well as survival after ICU discharge in patients with acute myeloid leukemia (AML) requiring treatment in the ICU. METHODS AND RESULTS: Multivariate analysis of data for 187 adults with AML treated in the ICU in one institution revealed the following as independent prognostic factors for death in the ICU: arterial oxygen partial pressure below 72 mmHg, active AML and systemic inflammatory response syndrome upon ICU admission, and need for hemodialysis and mechanical ventilation in the ICU. Based on these variables, we developed an ICU mortality score and validated the score in an independent cohort of 264 patients treated in the ICU in three additional tertiary hospitals. Compared with the Simplified Acute Physiology Score (SAPS) II, the Logistic Organ Dysfunction (LOD) score, and the Sequential Organ Failure Assessment (SOFA) score, our score yielded a better prediction of ICU mortality in the receiver operator characteristics (ROC) analysis (AUC = 0.913 vs. AUC = 0.710 [SAPS II], AUC = 0.708 [LOD], and 0.770 [SOFA] in the training cohort; AUC = 0.841 for the developed score vs. AUC = 0.730 [SAPSII], AUC = 0.773 [LOD], and 0.783 [SOFA] in the validation cohort). Factors predicting decreased survival after ICU discharge were as follows: relapse or refractory disease, previous allogeneic stem cell transplantation, time between hospital admission and ICU admission, time spent in ICU, impaired diuresis, Glasgow Coma Scale

Titel: Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction
Verfasser: Pohlen, Michéle Yvonne GND
Thoennißen, Nils Heinrich GND
Braess, Jan GND
Thudium, Johannes
Schmidt, Christoph
Kochanek, Matthias GND
Kreuzer, Karl-Anton GND
Lebiedz, Pia GND
Görlich, Dennis
Gerth, Ulrich GND
Rohde, Christian
Keßler, Torsten GND
Müller-Tidow, Carsten GND
Stelljes, Matthias
Büchner, Thomas
Schlimok, Günter GND
Hallek, Michael
Waltenberger, Johannes
Hiddemann, Wolfgang GND
Berdel, Wolfgang E. GND
Heilmeier, Bernhard GND
Krug, Utz GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 30.08.2016
Publikation in MIAMI: 29.12.2016
Datum der letzten Änderung: 29.12.2016
Quelle: PLoS ONE 11 (2016) 8, e0160871, 1-16
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster)
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-83269517453
DOI: 10.1371/journal.pone.0160871
ISSN: 1932-6203