Radiotherapy in the GHSG HD 16 and HD 17 trials – quality assurance and dosimetric analysis for Hodgkin lymphoma in the modern era

Introduction: Radiotherapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. The following analysis reports on RT-quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods: All RT-plans of involved-node RT (INRT) in HD 17 were requested...

Verfasser: Oertel, Michael
Hering, Dominik Alexander
Nacke, Nina
Kittel, Christopher
Kröger, Kai Jannes
Kriz, Jan
Fuchs, Michael
Baues, Christian Manfred
Vordermark, Dirk
Engenhart, Rita
Herfarth, Klaus
Lukas, Peter
Schmidberger, Heinz
Marnitz-Schulze, Simone
Borchmann, Peter
Engert, Andreas
Haverkamp, Uwe
Eich, Hans-Theodor
FB/Einrichtung:FB 05: Medizinische Fakultät
Dokumenttypen:Artikel
Medientypen:Text
Erscheinungsdatum:2022
Publikation in MIAMI:05.01.2023
Datum der letzten Änderung:05.01.2023
Angaben zur Ausgabe:[Electronic ed.]
Quelle:Advances in Radiation Oncology (2022), 101169
Fachgebiet (DDC):610: Medizin und Gesundheit
Lizenz:CC BY-NC-ND 4.0
Sprache:English
Format:PDF-Dokument
URN:urn:nbn:de:hbz:6-51069416122
Weitere Identifikatoren:DOI: 10.17879/51069418081
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-51069416122
Verwandte Dokumente:
Onlinezugriff:10.1016_j.adro.2022.101169.pdf

Introduction: Radiotherapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. The following analysis reports on RT-quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods: All RT-plans of involved-node RT (INRT) in HD 17 were requested for analysis, along with 100 and 50 involved-field RT (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding field design and protocol adherence was performed by the reference radiation oncology panel of the GHSG. Results: Overall, 100 (HD 16) and 176 (HD 17) patients were eligible for analysis. In HD 16, 84 % of RT series were evaluated as correct, with significant improvement compared to the predecessor studies (p< 0.001). In HD 17, 76.1 % of INRT-cases revealed a correct RT design compared to 69.1 % of IFRT-cases, which was superior to prior studies (p