Radiotherapy in the GHSG HD 16 and HD 17 trials – quality assurance and dosimetric analysis for Hodgkin lymphoma in the modern era
Introduction: Radiotherapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. The following analysis reports on RT-quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods: All RT-plans of involved-node RT (INRT) in HD 17 were requested...
| Authors: | |
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| Division/Institute: | FB 05: Medizinische Fakultät |
| Document types: | Article |
| Media types: | Text |
| Publication date: | 2022 |
| Date of publication on miami: | 05.01.2023 |
| Modification date: | 05.01.2023 |
| Edition statement: | [Electronic ed.] |
| Source: | Advances in Radiation Oncology (2022), 101169 |
| DDC Subject: | 610: Medizin und Gesundheit |
| License: | CC BY-NC-ND 4.0 |
| Language: | Englisch |
| Format: | PDF document |
| URN: | urn:nbn:de:hbz:6-51069416122 |
| Other Identifiers: | DOI: 10.17879/51069418081 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-51069416122 |
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| Digital documents: | 10.1016_j.adro.2022.101169.pdf |
Introduction: Radiotherapy (RT) is an integral part of treatment concepts for early-stage Hodgkin lymphoma. The following analysis reports on RT-quality in the recent HD16 and 17 trials of the German Hodgkin Study Group (GHSG). Methods: All RT-plans of involved-node RT (INRT) in HD 17 were requested for analysis, along with 100 and 50 involved-field RT (IFRT) plans in HD 16 and 17, respectively. A structured assessment regarding field design and protocol adherence was performed by the reference radiation oncology panel of the GHSG. Results: Overall, 100 (HD 16) and 176 (HD 17) patients were eligible for analysis. In HD 16, 84 % of RT series were evaluated as correct, with significant improvement compared to the predecessor studies (p< 0.001). In HD 17, 76.1 % of INRT-cases revealed a correct RT design compared to 69.1 % of IFRT-cases, which was superior to prior studies (p