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A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis

The quest for novel therapeutic targets in acute myeloid leukemia (AML) is still ongoing. One of such targets, cyclin A1, was shown to be overexpressed in AML including AML stem cells. However, the function of cyclin A1 in AML is largely unknown, and the data on its impact on patients´ survival remain controversial. Therefore, we developed a transgenic mouse model of stem cell-directed inducible cyclin A1 overexpression and crossed these mice with PML-RARα-knockin mice, which develop an AML M3-like phenotype. To observe the effects of cyclin A1 loss-of-function, we also crossed PML-RARα-knockin mice to cyclin A1-knockout mice. Neither overexpression nor loss of cyclin A1 significantly altered leukemogenesis in PML-RARα-knockin mice. These findings imply that upregulation of cyclin A1 is not essential for leukemogenesis. Our data suggest that cyclin A1 does not represent a suitable target for AML therapy.

Titel: A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis
Verfasser: Bäumer, Nicole GND
Bäumer, Sebastian Andreas GND
Haak, Miriam
Koschmieder, Steffen GND
Schönig, Kai GND
Berdel, Wolfgang E. GND
Müller-Tidow, Carsten GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 16.06.2015
Publikation in MIAMI: 13.08.2015
Datum der letzten Änderung: 30.09.2015
Quelle: PLoS ONE 10 (2015) 6, e0129147, 1-10
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-38279454427
DOI: 10.1371/journal.pone.0129147
ISSN: 1932-6203