Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation
Fast metabolism of immediate-release tacrolimus (IR-Tac) is associated with decreased kidney function after renal transplantation (RTx) compared to slow metabolizers. We hypothesized, by analogy, that fast metabolism of extended-release tacrolimus (ER-Tac) is associated with worse renal function. We...
| Verfasser: | |
|---|---|
| FB/Einrichtung: | FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2021 |
| Publikation in MIAMI: | 21.03.2023 |
| Datum der letzten Änderung: | 21.03.2023 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Scientific Reports 11 (2021), 15606, 1-13 |
| Schlagwörter: | Medical research; Nephrology |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY 4.0 |
| Sprache: | English |
| Förderung: | Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022. |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-00099446183 |
| Weitere Identifikatoren: | DOI: 10.17879/60099444821 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-00099446183 |
| Verwandte Dokumente: |
|
| Onlinezugriff: | 10.1038_s41598-021-95201-5.pdf |
Fast metabolism of immediate-release tacrolimus (IR-Tac) is associated with decreased kidney function after renal transplantation (RTx) compared to slow metabolizers. We hypothesized, by analogy, that fast metabolism of extended-release tacrolimus (ER-Tac) is associated with worse renal function. We analyzed data from patients who underwent RTx at three different transplant centers between 2007 and 2016 and received an initial immunosuppressive regimen with ER-Tac, mycophenolate, and a corticosteroid. Three months after RTx, a Tac concentration to dose ratio (C/D ratio)