Environmental adaptation of 'Acanthamoeba castellanii' and 'Entamoeba histolytica' at genome level as seen by comparative genomic analysis

Amoebozoans are in many aspects interesting research objects, as they combine features of single-cell organisms with complex signaling and defense systems, comparable to multicellular organisms. 'Acanthamoeba castellanii' is a cosmopolitan species and developed diverged feeding abilities a...

Authors: Shabardina, Victoria
Kischka, Tabea
Kmita, Hanna
Suzuki, Yutaka
Makałowski, Wojciech
Division/Institute:FB 05: Medizinische Fakultät
Document types:Article
Media types:Text
Publication date:2018
Date of publication on miami:21.03.2019
Modification date:27.01.2020
Edition statement:[Electronic ed.]
Source:International Journal of Biological Sciences 14 (2018) 3, 306-320
Subjects:Life strategy; genomic adaptation; comparative genomics; Acanthamoeba castellanii; Entamoeba histolytica
DDC Subject:610: Medizin und Gesundheit
License:CC BY-NC 4.0
Language:English
Funding:Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
URN:urn:nbn:de:hbz:6-45159505614
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-45159505614
Other Identifiers:DOI: 10.7150/ijbs.23869
Digital documents:artikel_makalowski_2018.pdf

Amoebozoans are in many aspects interesting research objects, as they combine features of single-cell organisms with complex signaling and defense systems, comparable to multicellular organisms. 'Acanthamoeba castellanii' is a cosmopolitan species and developed diverged feeding abilities and strong anti-bacterial resistance; 'Entamoeba histolytica' is a parasitic amoeba, who underwent massive gene loss and its genome is almost twice smaller than that of 'A. castellanii'. Nevertheless, both species prosper, demonstrating fitness to their specific environments. Here we compare transcriptomes of 'A. castellanii' and 'E. histolytica' with application of orthologs' search and gene ontology to learn how different life strategies influence genome evolution and restructuring of physiology. 'A. castellanii' demonstrates great metabolic activity and plasticity, while 'E. histolytica' reveals several interesting features in its translational machinery, cytoskeleton, antioxidant protection, and nutritional behavior. In addition, we suggest new features in 'E. histolytica' physiology that may explain its successful colonization of human colon and may facilitate medical research.