Influence of tacrolimus metabolism rate on BKV infection after kidney transplantation

Immunosuppression is the major risk factor for BK virus nephropathy (BKVN) after renal transplantation (RTx). As the individual tacrolimus (Tac) metabolism rate correlates with Tac side effects, we hypothesized that Tac metabolism might also influence the BKV infection risk. In this case-control stu...

Authors: Thölking, Gerold Bernhard
Schmidt, Christina
Koch, Raphael
Schütte-Nütgen, Katharina
Pabst, Dirk
Wolters, Heiner
Kabar, Iyad
Hüsing, Anna Katharina Elisabeth Pia
Pavenstädt, Hermann
Reuter, Stefan Johannes
Suwelack, Barbara
Division/Institute:FB 05: Medizinische Fakultät
Document types:Article
Media types:Text
Publication date:2016
Date of publication on miami:08.05.2017
Modification date:23.01.2020
Edition statement:[Electronic ed.]
Source:Scientific Reports 6 (2016) 32273, 1-8
DDC Subject:610: Medizin und Gesundheit
License:CC BY 4.0
Language:English
Notes:Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
ISSN:2045-2322
URN:urn:nbn:de:hbz:6-82239633479
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-82239633479
Other Identifiers:DOI: 10.1038/srep32273
Digital documents:Th-lking_et_al-2016-Scientific_Reports.pdf

Immunosuppression is the major risk factor for BK virus nephropathy (BKVN) after renal transplantation (RTx). As the individual tacrolimus (Tac) metabolism rate correlates with Tac side effects, we hypothesized that Tac metabolism might also influence the BKV infection risk. In this case-control study RTx patients with BK viremia within 4 years after RTx (BKV group) were compared with a BKV negative control group. The Tac metabolism rate expressed as the blood concentration normalized by the daily dose (C/D ratio) was applied to assess the Tac metabolism rate. BK viremia was detected in 86 patients after a median time of 6 (0–36) months after RTx. BKV positive patients showed lower Tac C/D ratios at 1, 3 and 6 months after RTx and were classified as fast Tac metabolizers. 8 of 86 patients with BK viremia had histologically proven BKN and a higher median maximum viral load than BKV patients without BKN (441,000 vs. 18,572 copies/mL). We conclude from our data that fast Tac metabolism (C/D ratio