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A computational model unifies apparently contradictory findings concerning phantom pain

Amputation often leads to painful phantom sensations, whose pathogenesis is still unclear. Supported by experimental findings, an explanatory model has been proposed that identifies maladaptive reorganization of the primary somatosensory cortex (S1) as a cause of phantom pain. However, it was recently found that BOLD activity during voluntary movements of the phantom positively correlates with phantom pain rating, giving rise to a model of persistent representation. In the present study, we develop a physiologically realistic, computational model to resolve the conflicting findings. Simulations yielded that both the amount of reorganization and the level of cortical activity during phantom movements were enhanced in a scenario with strong phantom pain as compared to a scenario with weak phantom pain. These results suggest that phantom pain, maladaptive reorganization, and persistent representation may all be caused by the same underlying mechanism, which is driven by an abnormally enhanced spontaneous activity of deafferented nociceptive channels.

Titel: A computational model unifies apparently contradictory findings concerning phantom pain
Verfasser: Boström, Kim GND
Lussanet, Marc H. E. de
Weiß, Thomas GND
Puta, Christian GND
Wagner, Heiko
Organisation: FB 05: Medizinische Fakultät
FB 07: Psychologie und Sportwissenschaft
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 16.06.2014
Publikation in MIAMI: 21.11.2014
Datum der letzten Änderung: 16.04.2019
Quelle: Scientific Reports 4 (2014) 5298, 1-9
Schlagwörter: Computational models; Network models; Chronic pain; Somatosensory system
Fachgebiete: Sportarten, Sportspiele
Lizenz: CC BY-NC-SA 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2014/2015 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-91339564480
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-91339564480
DOI: doi:10.1038/srep05298
ISSN: 2045-2322
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