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A Large N400 but No BOLD Effect – Comparing Source Activations of Semantic Priming in Simultaneous EEG-fMRI

Numerous studies have reported neurophysiological effects of semantic priming in electroencephalography (EEG) and in functional magnetic resonance imaging (fMRI). Because of differing methodological constraints, the comparability of the observed effects remains unclear. To directly compare EEG and fMRI effects and neural sources of semantic priming, we conducted a semantic word-picture priming experiment while measuring EEG and fMRI simultaneously. The visually presented primes were pseudowords, words unrelated to the target, semantically related words and the identical names of the target. Distributed source analysis of the event-related potentials (ERPs) successfully revealed a large effect of semantic prime-target relatedness (the N400 effect), which was driven by activations in a left-temporal source region. However, no significantly differing activations between priming conditions were found in the fMRI data. Our results support the notion that, for joint interpretations of existing EEG and fMRI studies of semantic priming, we need to fully appreciate the respective methodological limitations. Second, they show that simultaneous EEG-fMRI, including ERP source localization, is a feasible and promising methodological advancement for the investigation of higher-cognitive processes. Third, they substantiate the finding that, compared to fMRI, ERPs are often more sensitive to subtle cognitive effects.

Titel: A Large N400 but No BOLD Effect – Comparing Source Activations of Semantic Priming in Simultaneous EEG-fMRI
Verfasser: Geukes, Sebastian GND
Huster, René J. GND
Wollbrink, Andreas
Junghöfer, Markus
Zwitserlood, Pienie
Dobel, Christian
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 31.12.2013
Publikation in MIAMI: 19.02.2014
Datum der letzten Änderung: 05.09.2014
Quelle: PLoS ONE 8 (2013) 12, e84029
Fachgebiete: Psychologie
Lizenz: CC BY 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2013/2014 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-44319495707
DOI: 10.1371/journal.pone.0084029