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SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection

Molecular imaging techniques such as single photon emission computed tomography (SPECT) or positron emission tomography are promising tools for noninvasive diagnosis of acute allograft rejection (AR). Given the importance of renal transplantation and the limitation of available donors, detailed analysis of factors that affect transplant survival is important. Episodes of acute allograft rejection are a negative prognostic factor for long-term graft survival. Invasive core needle biopsies are still the “goldstandard” in rejection diagnostics. Nevertheless, they are cumbersome to the patient and carry the risk of significant graft injury. Notably, they cannot be performed on patients taking anticoagulant drugs. Therefore, a noninvasive tool assessing the whole organ for specific and fast detection of acute allograft rejection is desirable. We herein review SPECT- and PET-based approaches for noninvasive molecular imaging-based diagnostics of acute transplant rejection.

Titel: SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection
Verfasser: Pawelski, Helga GND
Schnöckel, Uta GND
Kentrup, Dominik GND
Grabner, Alexander GND
Schäfers, Michael
Reuter, Stefan Johannes GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 01.04.2014
Publikation in MIAMI: 25.11.2016
Datum der letzten Änderung: 16.04.2019
Quelle: Biomed Research International (2014) 874785, 7
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 3.0 DE
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2013/2014 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-24209573503
DOI: 10.1155/2014/874785
ISSN: 2314-6141