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OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients

Optical coherence tomography angiography (OCT-A) represents the most recent tool in ophthalmic imaging. It allows for a non-invasive, depth-selective and quantitative visualization of blood flow in central retinal vessels and it has an enormous diagnostic potential not only in ophthalmology but also with regards to neurologic and systemic diseases. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary vascular small-vessel disease caused by Notch3 mutations and represents the most common form of hereditary stroke disorder. In this study, CADASIL patients prospectively underwent OCT-A imaging to evaluate retinal and choriocapillaris blood flow as well as blood flow at the optic nerve head. The vessel density of the macular region and the size of the foveal avascular zone in the superficial and deep retinal plexus were determined as well as the vessel density at the optic nerve head and in the choriocapillaris. Additionally, cerebral magnetic resonance images were evaluated. The main finding was that vessel density of the deep retinal plexus was significantly decreased in CADASIL patients compared to healthy controls which may reflect pericyte dysfunction in retinal capillaries.

Titel: OCT-Angiography reveals reduced vessel density in the deep retinal plexus of CADASIL patients
Verfasser: Nelis, Pieter GND
Kleffner, Ilka GND
Burg, Matthias GND
Clemens, Christoph R. GND
Alnawaiseh, Maged GND
Motte, Jeremias GND
Marziniak, Martin GND
Eter, Nicole GND
Alten, Florian GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 25.05.2018
Publikation in MIAMI: 09.05.2019
Datum der letzten Änderung: 09.05.2019
Quelle: Scientific Reports 8 (2018) 8148, 1-7
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 4.0
Sprache: Englisch
Förderung: Finanziert durch den Open-Access-Publikationsfonds 2018 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-55109568066
DOI: 10.1038/s41598-018-26475-5