Surprisingly high number of Twintrons in vertebrates

Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in ins...

Authors: Janice, Jessin
Jąkalski, Marcin
Makałowski, Wojciech
Division/Institute:FB 13: Biologie
FB 05: Medizinische Fakultät
Document types:Article
Media types:Text
Publication date:2013
Date of publication on miami:12.03.2013
Modification date:27.01.2020
Edition statement:[Electronic ed.]
Source:Biology Direct 8 (2013) 4
Subjects:Twintrons; Vertebrate genomes; Gene expression
DDC Subject:610: Medizin und Gesundheit
License:CC BY 2.0
Language:English
Notes:Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
URN:urn:nbn:de:hbz:6-87359538868
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-87359538868
Other Identifiers:DOI: 10.1186/1745-6150-8-4
Digital documents:1745-6150-8-4.pdf

Twintrons represent a special intronic arrangement in which introns of two different types occupy the same gene position. Consequently, alternative splicing of these introns requires two different spliceosomes competing for the same RNA molecule. So far, only two twintrons have been described in insects. Surprisingly, we discovered several such arrangements in vertebrate genomes, which are quite conserved throughout the lineages. Reviewers: This article was reviewed by Fyodor Kondrashow and Eugene Koonin.