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|a urn:nbn:de:hbz:6-77159467058
|2 urn
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|a 10.1155/2017/9126560
|2 doi
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|a eng
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|a 610 Medizin und Gesundheit
|2 23
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|a Spiekermann, Christoph Otto
|0 http://d-nb.info/gnd/1042639957
|0 http://viaf.org/viaf/305268274
|4 aut
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|a Universitäts- und Landesbibliothek Münster
|0 http://d-nb.info/gnd/5091030-9
|4 own
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|a Increased Levels of S100A8/A9 in Patients with Peritonsillar Abscess: A New Promising Diagnostic Marker to Differentiate between Peritonsillar Abscess and Peritonsillitis
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|a [Electronic ed.]
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|c 2017-10-17
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|b Universitäts- und Landesbibliothek Münster
|c 2018-08-31
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|a 1-10
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|a free access
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|a Disease Markers (2017) Article ID 912656, 1-10
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|a Peritonsillar abscess (PTA) is a very frequent reason for urgent outpatient consultation and otolaryngological hospital admission. Early, correct diagnosis and therapy of peritonsillar abscess are important to prevent possible life-threatening complications. Based on physical examinations, a reliable differentiation between peritonsillar cellulitis and peritonsillar abscess is restricted. A heterodimeric complex called calprotectin consists of the S100 proteins A8 and A9 (S100A8/A9) and is predominantly expressed not only in monocytes and neutrophils but also in epithelial cells. Due to its release by activated phagocytes at local sites of inflammation, we assumed S100A8/A9 to be a potential biomarker for peritonsillar abscess. We examined serum and saliva of patients with peritonsillitis, acute tonsillitis, peritonsillar abscess, and healthy controls and found significantly increased levels of S100A8/A9 in patients with PTA. Furthermore, we could identify halitosis, trismus, uvula edema, and unilateral swelling of the arched palate to be characteristic symptoms for PTA. Using a combination of these characteristic symptoms and S100A8/A9 levels, we developed a PTA score as an objective and appropriate tool to differentiate between peritonsillitis and peritonsillar abscess with a sensitivity of 92% and specificity of 93%.
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|a specialized
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|a Finanziert durch den Open-Access-Publikationsfonds 2017 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
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|a CC BY 4.0
|u http://creativecommons.org/licenses/by/4.0/
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|2 DRIVER Types
|a Artikel
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|2 DCMI Types
|a Text
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|a Russo, Antonella
|4 aut
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|a Stenner, Markus
|0 http://d-nb.info/gnd/128790482
|4 aut
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|a Rudack, Claudia
|4 aut
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|a Roth, Johannes
|u FB 05: Medizinische Fakultät
|4 aut
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|a Vogl, Thomas
|0 http://d-nb.info/gnd/1115013424
|0 http://viaf.org/viaf/11147543492753190493
|4 aut
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|3 Zum Volltext
|q text/html
|u https://nbn-resolving.de/urn:nbn:de:hbz:6-77159467058
|u urn:nbn:de:hbz:6-77159467058
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|3 Zum Volltext
|q application/pdf
|u https://repositorium.uni-muenster.de/document/miami/436e86bc-980a-4250-a2fa-3544bd643e3e/artikel_spiekermann_2017.pdf
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