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Retrospective analysis of antimicrobial resistance and bacterial spectrum of infection in Gabon, Central Africa

Background: Physicians depend on reliable information on the local epidemiology of infection and antibiotic resistance rates to guide empiric treatment in critically ill patients. As these data are scarce for Central Africa, we performed a retrospective analysis of microbiological findings from a secondary care hospital in Gabon. Methods: Microbiological reports from 2009 to 2012 were used to assess the non-susceptibility rates of the three most common isolates from six major types of infections (bloodstream, ear-eye-nose-throat, surgical site, skin and soft tissue, urinary tract and wound infection). Results: A high diversity of pathogens was found, but Staphylococcus aureus was predominant in the majority of infections. Overall, the three most prevalent pathogens in children were S. aureus (33.7%), Streptococcus pyogenes (8.1%) and Escherichia coli (4.5%) and in adults S. aureus (23.5%), E. coli (15.1%) and Klebsiella pneumoniae (7.4%). In total, 5.8% (n = 19) of all S. aureus isolates were methicillin resistant. The proportion of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae was 15.4% (n = 78), 49.4% of all K. pneumoniae were ESBL-producer (n = 42). Conclusion: The high diversity of potential pathogens and high resistance rates in Gram-negative bacteria challenge a rational empiric use of antibiotics. Countrywide continuous sentinel surveillance is therefore urgently needed.

Titel: Retrospective analysis of antimicrobial resistance and bacterial spectrum of infection in Gabon, Central Africa
Verfasser: Alabi, Abraham S.
Frielinghaus, Lisa GND
Kaback, Harry GND
Kösters, Katrin GND
Huson, Michaëla A. M.
Kahl, Barbara C. GND
Peters, Georg
Grobusch, Martin GND
Issifou, Saadou GND
Kremsner, Peter G.
Schaumburg, Frieder GND
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 02.10.2013
Publikation in MIAMI: 24.02.2014
Datum der letzten Änderung: 16.04.2019
Quelle: BMC Public Health 13 (2013) 455
Schlagwörter: Antimicrobial resistance; Epidemiology; Africa; Staphylococcus aureus; ESBL
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 2.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2013/2014 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-94309469754
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-94309469754
DOI: 10.1186/1471-2334-13-455
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