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Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain

Background: Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil. Methods: The effects of different concentrations of anise oil were tested on seizure attacks induced by pentylenetetrazol (PTZ) injection and neuronal hypoxia induced by oxygen withdrawal as well as on production of dark neurons and induction of long-term potentiation (LTP) in in vivo and in vitro experimental models of rat brain. Results: Anise oil significantly prolonged the latency of seizure attacks and reduced the amplitude and duration of epileptiform burst discharges induced by injection of intraperitoneal PTZ. In addition, anise oil significantly inhibited production of dark neurons in different regions of the brain in epileptic rats. Anise oil also significantly enhanced the duration of the appearance of anoxic terminal negativity induced by oxygen withdrawal and inhibited induction of LTP in hippocampal slices. Conclusions: Our data indicate the anticonvulsant and neuroprotective effects of anise oil, likely via inhibition of synaptic plasticity. Further evaluation of anise oil to use in the treatment of neurological disorders is suggested.

Titel: Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain
Verfasser: Karimzadeh, Fariba
Hosseini, Mahmoud GND
Mangeng, Diana Silke Jasmin GND
Alavi, Hassan
Hassanzadeh, Gholam Reza
Bayat, Mohamad
Jafarian, Maryam
Weyssari, Hadi K. GND
Gorji, Ali
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 18.06.2012
Publikation in MIAMI: 06.03.2013
Datum der letzten Änderung: 16.04.2019
Quelle: BMC Complementary and Alternative Medicine 12 (2012) 76.
Schlagwörter: Cephalic pain; Stroke; Brain ischemia; Medical plants; Traditional therapy
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 2.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-47369423148
DOI: doi:10.1186/1472-6882-12-76