CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10

The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPC...

Authors: Heßner, Florian
Dlugos, Christopher Philipp Gerhard
Chehab, Tarek
Schaefer, C.
Homey, B.
Gerke, Volker
Weide, Thomas
Pavenstädt, Hermann
Rescher, Ursula
Division/Institute:FB 05: Medizinische Fakultät
FB 13: Biologie
Document types:Article
Media types:Text
Publication date:2016
Date of publication on miami:27.05.2016
Modification date:16.04.2019
Edition statement:[Electronic ed.]
Source:Scientific Reports 6 (2016) 22649, 1-9
DDC Subject:610: Medizin und Gesundheit
License:CC BY 4.0
Language:English
Notes:Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
ISSN:2045-2322
URN:urn:nbn:de:hbz:6-45289604790
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-45289604790
Other Identifiers:DOI: 10.1038/srep22649
Digital documents:srep22649.pdf

The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca2+ binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.