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CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10

The superfamily of G-protein-coupled receptors (GPCR) conveys signals in response to various endogenous and exogenous stimuli. Consequently, GPCRs are the most important drug targets. CCR10, the receptor for the chemokines CCL27/CTACK and CCL28/MEC, belongs to the chemokine receptor subfamily of GPCRs and is thought to function in immune responses and tumour progression. However, there is only limited information on the intracellular regulation of CCR10. We find that S100A10, a member of the S100 family of Ca2+ binding proteins, binds directly to the C-terminal cytoplasmic tail of CCR10 and that this interaction regulates the CCR10 cell surface presentation. This identifies S100A10 as a novel interaction partner and regulator of CCR10 that might serve as a target for therapeutic intervention.

Titel: CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10
Verfasser: Heßner, Florian GND
Dlugos, Christopher Philipp Gerhard GND
Chehab, Tarek GND
Schaefer, C.
Homey, B.
Gerke, Volker GND
Weide, Thomas GND
Pavenstädt, Hermann GND
Rescher, Ursula
Organisation: FB 05: Medizinische Fakultät
FB 13: Biologie
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 04.03.2016
Publikation in MIAMI: 27.05.2016
Datum der letzten Änderung: 16.09.2016
Quelle: Scientific Reports 6 (2016) 22649, 1-9
Fachgebiete: Medizin und Gesundheit
Lizenz: CC BY 4.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2015/2016 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-45289604790
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-45289604790
DOI: 10.1038/srep22649
ISSN: 2045-2322
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