|
|
|
|
| LEADER |
03345cam a2200373uu 4500 |
| 001 |
36a8452d-06fd-4f63-bc3e-91582e38b6d2 |
| 003 |
miami |
| 005 |
20190416 |
| 007 |
c||||||||||||a| |
| 008 |
190307e20190307||||||||||#s||||||||eng|||||| |
| 024 |
7 |
|
|a urn:nbn:de:hbz:6-85169494711
|2 urn
|
| 024 |
7 |
|
|a 10.3389/fnmol.2017.00345
|2 doi
|
| 041 |
|
|
|a eng
|
| 082 |
0 |
|
|a 610 Medizin und Gesundheit
|2 23
|
| 100 |
1 |
|
|a Rosso, Gonzalo
|0 http://d-nb.info/gnd/1128438321
|4 aut
|
| 110 |
2 |
|
|a Universitäts- und Landesbibliothek Münster
|0 http://d-nb.info/gnd/5091030-9
|4 own
|
| 245 |
1 |
0 |
|a Implications of Schwann Cells Biomechanics and Mechanosensitivity for Peripheral Nervous System Physiology and Pathophysiology
|
| 250 |
|
|
|a [Electronic ed.]
|
| 264 |
|
1 |
|c 2017-10-25
|
| 264 |
|
2 |
|b Universitäts- und Landesbibliothek Münster
|c 2019-03-07
|
| 300 |
|
|
|a 1-7
|
| 500 |
|
|
|a Frontiers in Molecular Neuroscience 10 (2017) 345, 1-7
|
| 506 |
0 |
|
|a free access
|
| 520 |
3 |
|
|a The presence of bones around the central nervous system (CNS) provides it with highly effective physiologically crucial mechanical protection. The peripheral nervous system (PNS), in contrast, lacks this barrier. Consequently, the long held belief is that the PNS is mechanically vulnerable. On the other hand, the PNS is exposed to a variety of physiological mechanical stresses during regular daily activities. This fact prompts us to question the dogma of PNS mechanical vulnerability. As a matter of fact, impaired mechanics of PNS nerves is associated with neuropathies with the liability to mechanical stresses paralleled by significant impairment of PNS physiological functions. Our recent biomechanical integrity investigations on nerve fibers from wild-type and neuropathic mice lend strong support in favor of natural mechanical protection of the PNS and demonstrate a key role of Schwann cells (SCs) therein. Moreover, recent works point out that SCs can sense mechanical properties of their microenvironment and the evidence is growing that SCs mechanosensitivity is important for PNS development and myelination. Hence, SCs exhibit mechanical strength necessary for PNS mechanoprotection as well as mechanosensitivity necessary for PNS development and myelination. This mini review reflects on the intriguing dual ability of SCs and implications for PNS physiology and pathophysiology.
|
| 521 |
|
|
|a specialized
|
| 536 |
|
|
|a Finanziert durch den Open-Access-Publikationsfonds 2017 der Westfälischen Wilhelms-Universität Münster (WWU Münster).
|
| 540 |
|
|
|a CC BY 4.0
|u http://creativecommons.org/licenses/by/4.0/
|
| 653 |
|
0 |
|a peripheral nervous system (PNS) development and regeneration
|a PMP22-associated PNS neuropathies
|a Schwann cells
|a mechanosensitivity
|a mechanical interactions between cells and the extracellular matrix
|
| 655 |
|
7 |
|2 DRIVER Types
|a Artikel
|
| 655 |
|
7 |
|2 DCMI Types
|a Text
|
| 700 |
1 |
|
|a Young, Peter
|u FB 05: Medizinische Fakultät
|0 http://d-nb.info/gnd/1123303657
|0 http://viaf.org/viaf/270128953
|4 aut
|
| 700 |
1 |
|
|a Shahin, Victor
|0 http://d-nb.info/gnd/123888522
|4 aut
|
| 856 |
4 |
0 |
|3 Zum Volltext
|q text/html
|u https://nbn-resolving.de/urn:nbn:de:hbz:6-85169494711
|u urn:nbn:de:hbz:6-85169494711
|
| 856 |
4 |
0 |
|3 Zum Volltext
|q application/pdf
|u https://repositorium.uni-muenster.de/document/miami/36a8452d-06fd-4f63-bc3e-91582e38b6d2/artikel_shahin_2017.pdf
|
