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Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP

Enterohemorrhagic E. coli (EHEC) causes severe diseases in humans worldwide. One of its virulence factors is EspP, which belongs to the serine protease autotransporters of Enterobacteriaceae (SPATE) family. In this review we recapitulate the current data on prevalence, biogenesis, structural properties and functionality. EspP has been used to investigate mechanistic details of autotransport, and recent studies indicate that this transport mechanism is not autonomous but rather dependent on additional factors. Currently, five subtypes have been identified (EspPα-EspPε), with EspPα being associated with highly virulent EHEC serotypes and isolates from patients with severe disease. EspPα has been shown to degrade major proteins of the complement cascade, namely C3 and C5 and probably interferes with hemostasis by cleavage of coagulation factor V. Furthermore, EspPα is believed to contribute to biofilm formation perhaps by polymerization to rope-like structures. Together with the proteolytic activity, EspPα might ameliorate host colonization and interfere with host response. 

Titel: Prevalence, Biogenesis, and Functionality of the Serine Protease Autotransporter EspP
Verfasser: Weiss, André
Brockmeyer, Jens GND
Organisation: FB 12: Chemie und Pharmazie
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 28.12.2012
Publikation in MIAMI: 27.02.2013
Datum der letzten Änderung: 16.04.2019
Quelle: Toxins 5 (2013) 1, 25-48
Schlagwörter: EspP; EHEC; virulence factor; SPATE; autotransporter; serine protease
Fachgebiete: Chemie
Lizenz: CC BY 3.0
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-17379538914
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-17379538914
DOI: 10.3390/toxins5010025
Onlinezugriff: