Differential effects of prediction error and adaptation along the auditory cortical hierarchy during deviance processing

Neural mismatch responses have been proposed to rely on different mechanisms, including prediction error-related activity and adaptation to frequent stimuli. However, the hierarchical cortical structure of these mechanisms is unknown. To investigate this question, we recorded hemodynamic responses w...

Verfasser: Schloßmacher, Insa
Dilly, Jacky
Protmann, Ina
Hofmann, David
Dellert, Torge
Roth-Paysen, Marie-Luise
Moeck, Robert
Bruchmann, Maximilian
Straube, Thomas
FB/Einrichtung:FB 05: Medizinische Fakultät
Dokumenttypen:Artikel
Medientypen:Text
Erscheinungsdatum:2022
Publikation in MIAMI:27.09.2022
Datum der letzten Änderung:13.02.2023
Angaben zur Ausgabe:[Electronic ed.]
Quelle:NeuroImage 259 (2022) 119445, 1-10
Schlagwörter:Adaptation; Prediction error; fMRI; Oddball; Deviance processing
Fachgebiet (DDC):610: Medizin und Gesundheit
Lizenz:CC BY-NC-ND 4.0
Sprache:English
Förderung:Finanziert durch den Open-Access-Publikationsfonds der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF-Dokument
URN:urn:nbn:de:hbz:6-62069432957
Weitere Identifikatoren:DOI: 10.17879/62069434159
Permalink:https://nbn-resolving.de/urn:nbn:de:hbz:6-62069432957
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  • Onlinezugriff:10.1016_j.neuroimage.2022.119445.pdf

    Neural mismatch responses have been proposed to rely on different mechanisms, including prediction error-related activity and adaptation to frequent stimuli. However, the hierarchical cortical structure of these mechanisms is unknown. To investigate this question, we recorded hemodynamic responses while participants (N = 54) listened to an auditory oddball sequence as well as a suited control condition. In addition to effects in sensory processing areas (Heschl's gyrus, superior temporal gyrus (STG)), we found several distinct clusters that indexed deviance processing in frontal and parietal regions (anterior cingulate cortex/supplementary motor area (ACC/SMA), inferior parietal lobule (IPL), anterior insula (AI), inferior frontal junction (IFJ)). Comparing responses to the control stimulus with the deviant and standard enabled us to delineate the contributions of prediction error- or adaptation-related brain activation, respectively. We observed significant effects of adaptation in Heschl's gyrus, STG and ACC/SMA, while prediction error-related activity was observed in STG, IPL, AI and IFJ. Additional dynamic causal modeling confirmed the superiority of a hierarchical processing structure compared to a flat structure. Thus, we found that while prediction-error related processes increased with the hierarchical level of the brain area, adaptation declined. This suggests that the relative contribution of different mechanisms in deviance processing varies across the cortical hierarchy.