Simvastatin induces adverse effects on proliferation and mineralization of human primary osteoblasts
Background:Frequently statins were administered to reduce the LDL-concentration in circulating blood. Especially simvastatin (SV) is an often prescribed statin. Pleiotropic effects of these drugs were reported. Thus, the aim of this study was to evaluate effects of SV on osteoblastic mineralization....
| Verfasser: | |
|---|---|
| FB/Einrichtung: | FB 05: Medizinische Fakultät |
| Dokumenttypen: | Artikel |
| Medientypen: | Text |
| Erscheinungsdatum: | 2020 |
| Publikation in MIAMI: | 22.02.2023 |
| Datum der letzten Änderung: | 22.02.2023 |
| Angaben zur Ausgabe: | [Electronic ed.] |
| Quelle: | Head & Face Medicine 16 (2020) 18, 1-9 |
| Schlagwörter: | Mineralization; Osteoblasts; Adverse effects; Simvastatin |
| Fachgebiet (DDC): | 610: Medizin und Gesundheit |
| Lizenz: | CC BY 4.0 |
| Sprache: | English |
| Förderung: | Finanziert über die DEAL-Vereinbarung mit Wiley 2019-2022. |
| Format: | PDF-Dokument |
| URN: | urn:nbn:de:hbz:6-71019437018 |
| Weitere Identifikatoren: | DOI: 10.17879/81019520868 |
| Permalink: | https://nbn-resolving.de/urn:nbn:de:hbz:6-71019437018 |
| Verwandte Dokumente: |
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| Onlinezugriff: | 10.1186_s13005-020-00232-4.pdf |
Background:Frequently statins were administered to reduce the LDL-concentration in circulating blood. Especially simvastatin (SV) is an often prescribed statin. Pleiotropic effects of these drugs were reported. Thus, the aim of this study was to evaluate effects of SV on osteoblastic mineralization. Methods:After informed consent primary osteoblasts were collected from tissue surplus after treatment of 14 individuals in the Department of Cranio-Maxillofacial Surgery, University Hospital Münster. The cells were passaged according to established protocols. Viability, mineralization capability and osteoblastic marker (alkaline phosphatase) were determined at day 9, 13 and 16 after adding various SV concentrations (0.05 μM, 0.1 μM, 0.5 μM, 1.0 μM). Statistical analysis was performed using the Kruskal-Wallis-test. Results:The cell cultures showed a time and dose-dependent significantly decreased viability (p