Serinol: small molecule - big impact

The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used...

Authors: Andreeßen, Björn
Steinbüchel, Alexander
Division/Institute:FB 13: Biologie
Document types:Article
Media types:Text
Publication date:2011
Date of publication on miami:06.11.2013
Modification date:21.01.2020
Edition statement:[Electronic ed.]
Source:AMB Express 1 (2011) 12
Subjects:2-Amino-1, 3-propanediol, Amino alcohol, Serinol
DDC Subject:570: Biowissenschaften; Biologie
Legal notice:Die folgenden Lizenzbestimmungen sind mit dieser Ressource verbunden: Creative Commons Lizenz (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/
License:CC BY 2.0
Language:English
Notes:Finanziert durch den Open-Access-Publikationsfonds 2011/2012 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format:PDF document
URN:urn:nbn:de:hbz:6-05329435744
Permalink:http://nbn-resolving.de/urn:nbn:de:hbz:6-05329435744
Other Identifiers:DOI: 10.1186/2191-0855-1-12
Digital documents:2191-0855-1-12.pdf

The amino alcohol serinol (2-amino-1,3-propanediol) has become a common intermediate for several chemical processes. Since the 1940s serinol was used as precursor for synthesis of synthetic antibiotics (chloramphenicol). In the last years, new scopes of applications were discovered. Serinol is used for X-ray contrast agents, pharmaceuticals or for chemical sphingosine/ceramide synthesis. It can either be obtained by chemical processes based on 2-nitro-1,3-propanediol, dihydroxyacetone and ammonia, dihydroxyacetone oxime or 5-amino-1,3- dioxane, or biotechnological application of amino alcohol dehydrogenases (AMDH) or transaminases. This review provides a survey of synthesis, properties and applications for serinol.