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Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16

Background: Promoter methylation of the tumor suppressor gene Cyclin A1 could be associated with Human Papillomavirus 16 (HPV16) induced Head and Neck Squamous Cell Carcinoma (HNSCC) and Cervical Carcinoma. There is disagreement about the impact of this epigenetic event on protein expression of Cyclin A1 in malignant and non-malignant tissue and there hardly exists any information about possible relationships between Cyclin A1 expression and clinicopathological characteristics in HNSCC. Methods: We analyzed protein expression of Cyclin A1 in 81 HNSCC and 74 benign tonsils by immunohistochemistry and correlated it to Cyclin A1 methylation status, presence of HPV16 infection and other clinicopathological characteristics. Results: Overexpression of Cyclin A1 was more present in HNSCC than in tonsils (p

Titel: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16
Verfasser: Weiss, Daniel
Koopmann, Mario GND
Basel, Türker GND
Rudack, Claudia
Organisation: FB 05: Medizinische Fakultät
Dokumenttyp: Artikel
Medientyp: Text
Erscheinungsdatum: 19.06.2012
Publikation in MIAMI: 06.03.2013
Datum der letzten Änderung: 17.08.2018
Quelle: BMC Cancer 12 (2012) 259
Schlagwörter: Head and neck squamous cell carcinoma; Cyclin A1; Promoter methylation; Human Papillomavirus 16
Fachgebiete: Medizin und Gesundheit
Rechtlicher Vermerk: Die folgenden Lizenzbestimmungen sind mit dieser Ressource verbunden: Creative Commons Lizenz (CC BY 2.0) http://creativecommons.org/licenses/by/2.0/
Lizenz: CC BY 3.0 DE
Sprache: Englisch
Anmerkungen: Finanziert durch den Open-Access-Publikationsfonds 2012/2013 der Deutschen Forschungsgemeinschaft (DFG) und der Westfälischen Wilhelms-Universität Münster (WWU Münster).
Format: PDF-Dokument
URN: urn:nbn:de:hbz:6-47369417360
Permalink: https://nbn-resolving.org/urn:nbn:de:hbz:6-47369417360
DOI: doi:10.1186/1471-2407-12-259
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