protein evolution Bacillus thuringiensis Cnidaria De novo genes Domain Domain arrangement Domain similarity Host-parasite interactions Multiple alignment Oral infection Orthology Pricking infection RNA sequencing Similarity Transcriptome Tribolium castaneum binding specificity de novo gene emergence de novo proteins domain rearrangements evolution of regulatory networks gene evolution genomics mathematical modeling mechanosensation multifunctionality nematocyst evolution neurobiology neutral networks transcriptional regulation